AIDS drug cocktails fail in the real world

日期:2019-02-26 14:10:01 作者:京谭糖 阅读:

By Michael Day HIGHLY publicised “triple therapies”—the latest big hope in AIDS treatment—are failing to live up to expectations, according to a San Francisco study. Its findings suggest that the precisely regulated course of pills is proving too complicated for most HIV-positive patients. In clinical trials, a cocktail of drugs including the latest protease inhibitors has produced astounding results. In some trials, levels of HIV in the blood fell below detectable amounts in 90 per cent of patients. But these studies relied on highly motivated volunteers who were likely to stick to the complex and demanding dosing schedules required and put up with any side effects of the treatment, says Steven Deeks of the University of California at San Francisco. His team has found that the picture is far less rosy with more typical patients. “We were looking at patients who were not the idealised research patients typically found in clinical trials,” says Deeks. Deeks studied 136 patients taking triple therapy. In 72 of them, HIV remained at detectable levels,